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This is the first study to evaluate the safety and viral shedding of LAIV in Chinese healthy juveniles and adults. LAIV has many advantages. LAIV imitates natural infection, stimulating mucosal and humoral immunity without causing severe illness. LAIV was produced by growing attenuated influenza viruses in chick embryo cells . These attenuated ...

Intranasal powder live attenuated influenza vaccine is ... - Nature

Recently, two randomized controlled trials (RCTs) assessing Russian-backbone trivalent LAIV in children reported contradictory results; vaccine efficacy varied between Bangladesh (41 %) and Senegal (0.0 %) against all influenza viral strains. Prior to 2013, Ann Arbor-based LAIV demonstrated superior efficacy as compared to IIV.

Types of seasonal influenza vaccine - World Health Organization (WHO)

Abstract. The USA has a long-standing paediatric influenza vaccination programme, including use of live attenuated influenza vaccine (LAIV). Following US evidence of apparent lack of vaccine effectiveness (VE) of LAIV in 2015/2016, particularly against A (H1N1)pdm09, the USA suspended the use of LAIV in the 2016/2017 season.

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